منابع مشابه
Regulation of ribosomal gene transcription.
In eukaryotic cells, ribosomal RNA (rRNA) gene is transcribed by RNA polymerase I (pol I) in the nucleolus as a large (40 S-47 S) precursor RNA (pre-rRNA) (for reviews, see refs. [1,2]). The mature rRNA species (28 S, 18 S and 5.8 S) are formed after a series of specific endonucleolytic cleavage reactions (for a review, see ref. [3]). The rRNA gene (rDNA) is highly reiterated and is arranged in...
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The mucin 1 (MUC1) heterodimeric protein is aberrantly overexpressed in human breast cancers and induces transformation. The MUC1 COOH-terminal subunit (MUC1-C) is targeted to the nucleus of transformed cells, where it interacts with p53 and regulates p53-mediated transcription. The present studies show that MUC1 represses activation of the p53 gene and that MUC1-C occupies the PE21 element in ...
متن کاملTaVRT2 represses transcription of the wheat vernalization gene TaVRN1.
In wheat, VRN1/TaVRN1 and VRN2/TaVRN2 determine the growth habit and flowering time. In addition, the MADS box transcription factor VEGETATIVE TO REPRODUCTIVE TRANSITION 2 (TaVRT2) is also associated with the vernalization response in a manner similar to TaVRN2. However, the molecular relationship between these three genes and their products is unknown. Using transient expression assays in Nico...
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Expression of mdr-1 is complex and highly regulated. Several lines of evidence indirectly suggest that transcription factor c-Jun may negatively regulate human mdr-1 gene expression. We recently found that salvicine, a novel topoisomerase II inhibitor, is cytotoxic for multidrug resistance (MDR) tumor cells and down-regulates mdr-1 expression in MDR K562/A02 cells. Salvicine also stimulates a s...
متن کاملp53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53.
The transcription program of the hepatitis B virus (HBV) genome is regulated by an enhancer element that binds multiple ubiquitous and liver-enriched transcription activators. HBV transcription and replication are repressed in the presence of p53. Here we describe a novel molecular mechanism that is responsible for this repression. The p53 protein binds to a defined region within the HBV enhanc...
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ژورنال
عنوان ژورنال: Oncogene
سال: 1999
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1202402